In addition, 5-HT1A/2A/2C receptor agonists have shown anti-inflammatory properties, and there is growing evidence that inflammation is another process implicated in the pathogenesis of anxiety and depression . They highlighted findings that 5-HT1A receptor agonists have shown antidepressive and anxiolytic effects in both humans and animals, and 5-HT2A/2C agonists had antidepressive and anxiolytic effects in animal studies. While cocaine increases dopamine efflux and reuptake inhibition in both the shell and core of the nucleus accumbens, harmine only augments efflux in the shell of the nucleus accumbens 140, 147, perhaps demonstrating one mechanism of harmine that is similar to cocaine that can be useful in treatment and has far less addictive potential.
